Detection and localization of recurrent prostate cancer is critical for optimal patient management1

1 in 3 men treated for primary prostate cancer experiences a biochemical recurrence1

Up to one-third of men treated for primary prostate cancer will experience a biochemical recurrence (BCR) within 10 years.1 One-third of those men will develop metastatic disease within 8 years.1

Men treated for primary prostate cancer

1 in 3 men treated for primary prostate cancer experiences biochemical recurrence.

Limitations of current imaging procedures:

The most commonly used imaging procedures:

  • Have low detection rates: Positive findings occur in only ~11% of patients with biochemical recurrence.2 
  • May not detect small tumors: Some imaging procedures may be unable to detect recurrent prostate tumors <1 cm in size or when PSA levels are <10 ng/mL—when cancer may be more effectively managed or treated with localized therapy.3-8 
  • Difficult for everyday use: Some imaging procedures can be time consuming, or present challenges for reproducibility of results.9-11
  • May require multiple scans to evaluate all potential metastatic sites: Bone scans, CT, and/or MRI may be necessary.3
Inconclusive CT scan: Axial View. Without Axumin

Inconclusive CT imaging: Axial view. Post radical prostatectomy and negative lymphadenectomy with PSA elevated to 0.73 ng/mL. MR and earlier skeletal screening were negative for malignancy.

There is a clinical need for new tools, such as imaging agents, to better assess the location and extent of recurrent disease.12-15


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