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The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Prostate Cancer Version v2.2022 state that F 18 fluciclovine PET/CT or PET/MRI should be considered as options in the clinical workup of patients with recurrence or progression of nonmetastatic prostate cancer.
To view the full NCCN Guidelines® for Prostate Cancer Version v2.2022, visit www.nccn.org.
Optimum Imaging Strategies for Advanced Prostate Cancer states that for patients with rising PSA after local treatment who are considered suitable for salvage therapy, next-generation imaging (NGI), including F 18 fluciclovine PET, should be considered if conventional imaging is negative for metastasis.
To view the full ASCO Guidelines, including pocket guide and web-based flip chart, please visit www.asco.org/research-guidelines/quality-guidelines/guidelines.
The ACR Appropriateness Criteria® for Post-Treatment Follow-up of Prostate Cancer categorizes Axumin PET/CT skull base to mid-thigh as “usually appropriate” for post-treatment follow-up in certain situations.*
To view the full ACR Appropriateness Criteria® for Post-Treatment Follow-up of Prostate Cancer, visit www.acr.org.
The group discussed the potential impact of NGIs on treatment options based on earlier detection of disease. The RADAR III Group unanimously recommended NGI techniques for select patients suspected of disease progression based on laboratory (biomarker) values, comorbidities, and symptoms and that F 18 fluciclovine PET/CT is favorable due to the combination of availability, specificity, and sensitivity.
To review the full RADAR III review article, visit www.auajournals.org/doi/pdf/10.1016/j.juro.2018.05.164.
*Variant 1: Prostate cancer follow-up. Status post radical prostatectomy. Clinical concern for residual or recurrent disease; Variant 2: prostate cancer follow-up. Clinical concern for residual or recurrent disease after nonsurgical local and pelvic treatments; Variant 3: Metastatic prostate cancer treated by systemic therapy (androgen deprivation therapy [ADT], chemotherapy, and immunotherapy).
Axumin® (fluciclovine F 18) injection is indicated for positron emission tomography (PET) imaging in men with suspected prostate cancer recurrence based on elevated blood prostate specific antigen (PSA) levels following prior treatment.
Please see Axumin full Prescribing Information.